Immune targets in the tumor microenvironment treated by radiotherapy.

Radiotherapy (RT), the major anti-cancer modality for more than half of cancer patients after diagnosis, has the advantage of local tumor control with relatively less systematic side effects comparing to chemotherapy. However, the efficacy of RT is limited by acquired tumor resistance leading to the risks of relapse and metastasis. To further enhance the efficacy of RT, with the renaissances of targeted immunotherapy (TIT), increasing interests are raised on RT combined with TIT including cancer vaccines, T-cell therapy, and antibody-based immune checkpoint blockers (ICB) such as anti-CTLA-4 and anti-PD1/PD-L1. In achieving a significant synergy between RT and TIT, the dynamics of radiation-induced response in tumor cells and stromal cells, especially the cross-talk between tumor cells and immune cells in the irradiated tumor microenvironment (ITME) as highlighted in recent literature are to be elucidated. The abscopal effect refereeing the RT-induced priming function outside of ITME could be compromised by the immune-suppressive factors such as CD47 and PD-L1 on tumor cells and Treg induced or enhanced in the ITME. Cell surface receptors temporally or permanently induced and bioactive elements released from dead cells could serve antigenic source (radiation-associated antigenic proteins, RAAPs) to the host and have functions in immune regulation on the tumor. This review is attempted to summarize a cluster of factors that are inducible by radiation and targetable by antibodies, or have potential to be immune regulators to synergize tumor control with RT. Further characterization of immune regulators in ITME will deepen our understanding of the interplay among immune regulators in ITME and discover new effective targets for the combined modality with RT and TIT

Binocular contrast discrimination needs monocular multiplicative noise.

The effects of signal and noise on contrast discrimination are difficult to separate because of a singularity in the signal-detection-theory model of two-alternative forced-choice contrast discrimination (Katkov, Tsodyks, & Sagi, 2006). In this article, we show that it is possible to eliminate the singularity by combining that model with a binocular combination model to fit monocular, dichoptic, and binocular contrast discrimination. We performed three experiments using identical stimuli to measure the perceived phase, perceived contrast, and contrast discrimination of a cyclopean sine wave. In the absence of a fixation point, we found a binocular advantage in contrast discrimination both at low contrasts (<4%), consistent with previous studies, and at high contrasts (≥34%), which has not been previously reported. However, control experiments showed no binocular advantage at high contrasts in the presence of a fixation point or for observers without accommodation. We evaluated two putative contrast-discrimination mechanisms: a nonlinear contrast transducer and multiplicative noise (MN). A binocular combination model (the DSKL model; Ding, Klein, & Levi, 2013b) was first fitted to both the perceived-phase and the perceived-contrast data sets, then combined with either the nonlinear contrast transducer or the MN mechanism to fit the contrast-discrimination data. We found that the best model combined the DSKL model with early MN. Model simulations showed that, after going through interocular suppression, the uncorrelated noise in the two eyes became anticorrelated, resulting in less binocular noise and therefore a binocular advantage in the discrimination task. Combining a nonlinear contrast transducer or MN with a binocular combination model (DSKL) provides a powerful method for evaluating the two putative contrast-discrimination mechanisms

Asymptotically Optimal Multiple-access Communication via Distributed Rate Splitting

We consider the multiple-access communication problem in a distributed setting for both the additive white Gaussian noise channel and the discrete memoryless channel. We propose a scheme called Distributed Rate Splitting to achieve the optimal rates allowed by information theory in a distributed manner. In this scheme, each real user creates a number of virtual users via a power/rate splitting mechanism in the M-user Gaussian channel or via a random switching mechanism in the M-user discrete memoryless channel. At the receiver, all virtual users are successively decoded. Compared with other multiple-access techniques, Distributed Rate Splitting can be implemented with lower complexity and less coordination. Furthermore, in a symmetric setting, we show that the rate tuple achieved by this scheme converges to the maximum equal rate point allowed by the information-theoretic bound as the number of virtual users per real user tends to infinity. When the capacity regions are asymmetric, we show that a point on the dominant face can be achieved asymptotically. Finally, when there is an unequal number of virtual users per real user, we show that differential user rate requirements can be accommodated in a distributed fashion.Comment: Submitted to the IEEE Transactions on Information Theory. 15 Page

Weakly nonlinear quantum transport: an exactly solvable model

We have studied the weakly non-linear quantum transport properties of a two-dimensional quantum wire which can be solved exactly. The non-linear transport coefficients have been calculated and interesting physical properties revealed. In particular we found that as the incoming electron energy approaches a resonant point given by energy $E=E_r$, where the transport is characterized by a complete reflection, the second order non-linear conductance changes its sign. This has interesting implications to the current-voltage characteristics. We have also investigated the establishment of the gauge invariance condition. We found that for systems with a finite scattering region, correction terms to the theoretical formalism are needed to preserve the gauge invariance. These corrections were derived analytically for this model.Comment: 15 pages, LaTeX, submitted to Phys. Rev.